Portal da USP Portal da USP Portal da USP

Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release

Isabela Angeli de Lima, Suelen Plaza Pomin, Osvaldo Albuquerque Cavalcanti


Free films of pullulan-polymethacrylate associations were produced by casting process to develop a novel target-specific material. For characterization, tests of water vapor permeability, swelling index, infrared absorption spectroscopy, thermogravimetric analysis, scanning electron microscopy and mechanical analysis were performed. The polysaccharide concentration directly influenced vapor permeability and swelling, increasing the values of the latter up to five times when added in a proportion of 20% (per weight). The individual properties of each polymer were maintained, and chemical interactions were not detected. The films were found to be thermally stable and they had unaltered mechanical properties with the addition of the polysaccharide. The microscopic analysis revealed rugosity that was proportional to pullulan and disorganization of the polymer network at pH 6.8. These results suggest that this novel material has potential for enteric drug release because of synergism between pH and enzyme dependence.


Films; Polymeric material; Modified release/enteric release/oral delivery/controlled release; Glucans; Eudragit; Physicochemical characterization

Full Text:


DOI: http://dx.doi.org/10.1590/s2175-97902017000300002

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

SCImago Journal & Country Rank