Correlation between Myocardial Velocity Measured using Tissue Doppler Imaging in the Left Ventricular Lead-Implanted Segment and Response to Cardiac Resynchronization Therapy

Authors

  • Dong-Mei Yang University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology https://orcid.org/0000-0002-4638-3700
  • Fei Yu University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology https://orcid.org/0000-0003-4828-1377
  • Kang-Yu Chen University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology https://orcid.org/0000-0002-7095-6767
  • Hao Su University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology
  • Qi Wang University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology https://orcid.org/0000-0002-2186-8496
  • Zhi-Quan Liu University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology
  • Kai Hu University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology
  • Jian Xu University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology
  • Ji Yan University of Science and Technology of China, First Affiliated Hospital, Division of Cardiology https://orcid.org/0000-0002-2558-7210

DOI:

https://doi.org/10.6061/clinics/2019/e1077

Keywords:

Cardiac Resynchronization Therapy, Heart Failure, Echocardiography, Tissue Doppler Imaging

Abstract

OBJECTIVES: This study investigated whether tissue Doppler imaging parameters, especially the peak systolic velocity of the left ventricular lead-implanted segment (Ss), affect cardiac resynchronization therapy response. METHODS: In this case-control study, 110 enrolled patients were divided into cases (responder group, n=65) and controls (nonresponder group, n=45) based on whether their left ventricular end-systolic volume was reduced by X15% at 6 months after surgery. Preoperative clinical and echocardiographic data were collected. Multivariate logistic regression models were used to analyze the factors affecting the response to cardiac resynchronization therapy, and receiver operating characteristic curves were plotted to evaluate their diagnostic values. RESULTS: The proportion of patients with left bundle branch block in the case group was higher than that in the control group. The control group showed a higher left atrial volume index, E/A ratio and E/Em ratio but lower Ss than that of the case group. A multivariate regression analysis showed that left bundle branch block, Ss, and an E/Em ratio414 were independent risk factors affecting the response to cardiac resynchronization therapy. Ss=4.1 cm/s was the best diagnostic threshold according to the receiver operating characteristic curve. CONCLUSIONS: Ss is an important factor affecting the response to cardiac resynchronization therapy. Patients with heart failure associated with Sso4.1 cm/s have a higher risk of nonresponse.

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Published

2019-10-08

Issue

Section

Original Articles

How to Cite

Correlation between Myocardial Velocity Measured using Tissue Doppler Imaging in the Left Ventricular Lead-Implanted Segment and Response to Cardiac Resynchronization Therapy. (2019). Clinics, 74, e1077. https://doi.org/10.6061/clinics/2019/e1077