Effects of oxycodone hydrochloride and dezocine on hemodynamics and levels of inflammatory factors in patients receiving gynecological laparoscopic surgery under general anesthesia
DOI:
https://doi.org/10.1590/s2175-97902023e21129Keywords:
Gynecological laparoscopic surgery, Oxycodone hydrochloride, Dezocine, Hemodynamics, Inflammatory factorAbstract
We aimed to compare the effects of oxycodone hydrochloride and dezocine on hemodynamics and inflammatory factors in patients receiving gynecological laparoscopic surgery under general anesthesia. A total of 246 patients were divided into group A and B (n=123). Hemorheology indices were recorded 5 min after anesthesia (T0), 1 min after pneumoperitoneum (T1), when position was changed 5 min after pneumoperitoneum (T2), 15 min after pneumoperitoneum (T3), 1 min (T4) and 5 min (T5) after position was restored. Visual analogue scale scores 1, 2, 6, 12, 24 and 48 h after operation were recorded. Postoperative adverse reactions and visceral pain were observed. The expression levels of inflammatory factors were detected by enzyme-linked immunosorbent assay 12 h after operation. Compared with group A, group B had higher heart rate and mean arterial pressure at T2, lower central venous pressure and cardiac output at T1-T3, and higher systemic vascular resistance at T1-T5 (P<0.05). The incidence rate of pain syndrome in group A was lower (P<0.05). Group A had lower tumor necrosis factor-alpha and interleukin-6 expression levels and higher interleukin-10 level than those of group B (P<0.05). For gynecological laparoscopic surgery, oxycodone preemptive analgesia has superior outcomes to those of dezocine.
Downloads
References
Aktan B, Akbayrak T. Physiotherapy and rehabilitation in shoulder pain after gynecological laparoscopic surgery: a case report. Konuralp Med J. 2020;12(2):334-7.
Cho JS, Kim SW, Lee S, Yoo YC. Dose-ranging study of ramosetron for the prevention of nausea and vomiting after laparoscopic gynecological surgery: a prospective randomized study. J Clin Med. 2019;8(12):2188.
Cicchese JM, Evans S, Hult C, Joslyn LR, Wessler T, Millar JA, et al. Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology. Immunol Rev. 2018;285(1):147-67.
Han L, Ren RR, Wan KL, Yang L, Kang JQ. Plasma inflammatory factors in older people predict acute kidney injury: a case-control study. Eur Geriatr Med. 2019;10(6):905-11.
Kim NS, Kang KS, Yoo SH, Chung JH, Chung JW, Seo Y, et al. A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy. Korean J Anesthesiol. 2015;68(3):261-6.
Korolkiewicz P, Ali S, Szmuda T, Sloniewski P. A commentary on coffee consumption for recovery of intestinal function after laparoscopic gynecological surgery: A randomized controlled trial (Int J Surg 2020; 82:130-5). Int J Surg. 2021;85:29. https://pesquisa.bvsalud.org/controlecancer/resource/pt/mdl-33276166?src=similardocs
» https://pesquisa.bvsalud.org/controlecancer/resource/pt/mdl-33276166?src=similardocs
Kucharz J, Filipczak-Bryniarska I, Michalowska-Kaczmarczyk A, Herman RM, Krzemieniecki K. Use of high-dose oxycodone hydrochloride in patients with visceral and neuropathic pain. Contemp Oncol. 2015;19(3):257-9.
Kuffler DP. Mechanisms for reducing neuropathic pain. Mol Neurobiol. 2020;57(1):67-87.
Laughlin RS, Johnson RL, Burkle CM, Staff NP. Postsurgical Neuropathy: A Descriptive Review. Mayo Clin Proc. 2020;95(2):355-69.
Li XT, Ma CQ, Qi SH, Zhang LM. Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial. World J Clin Cases. 2019;7(20):3237-46.
Park JH, Lee C, Shin Y, An JH, Ban JS, Lee JH. Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after laparoscopic gynecological surgery. Korean J Anesthesiol. 2015;68(2):153-8.
Sao CH, Chan-Tiopianco M, Chung KC, Chen YJ, Horng HC, Lee WL, et al. Pain after laparoscopic surgery: Focus on shoulder-tip pain after gynecological laparoscopic surgery. J Chin Med Assoc. 2019;82(11):819-26.
Wang YX, Mao XF, Li TF, Gong N, Zhang MZ. Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptor activation and norepinephrine reuptake inhibition. Sci Rep. 2017;7:43137.
Zhao X, Zhou S, Wang L, Lin L, Chen L, Zhou J. Oxycodone versus morphine for titration analgesia after laparoscopic gynecologic surgery in postanesthesia care unit: A prospective, randomized trial. Mater Express. 2020;10(10):1771-6.
Zhou M, Wang L, Wu C, Yan L, Wang R, Sun B, et al. Reprint of: Efficacy and safety of different doses of dezocine for preemptive analgesia in gynecological laparoscopic surgeries: A prospective, double blind and randomized controlled clinical trial. Int J Surg. 2018;49:84-90.
Zhu YP, Liang S, Zhu L, Sun ZJ, Lang JH. Trocar-site hernia after gynecological laparoscopic surgery: a 20-year, single-center experience. Chin Med J. 2019;132(22):2677-83.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Brazilian Journal of Pharmaceutical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.
The on line journal has open and free access.
