Swing time as a predictive variable for Parkinson’s disease

Authors

DOI:

https://doi.org/10.1590/1809-2950/20028228012021

Keywords:

Parkinson s Disease, Gait, Kinematic, Eatly Diagnosis

Abstract

Currently, Parkinson’s Disease (PD) is diagnosed based only on the clinical observation of a symptom combination, which can lead to late diagnosis, since some individuals have the disease for 5 to 10 years before diagnosis. The aim of this study was to identify temporal kinematic variables of gait, capable of discriminating older adults with or without PD. Forty individuals were divided into two
groups: older adults without PD (n=21) and with PD (n=19). Ten consecutive gait cycles were obtained during gait at a preferred speed and then used in data analysis. Discriminative analysis
was performed to determine a  predictor model of gait changes,
characteristic of PD, estimated based on the specificity and sensitivity of each analyzed variable, with temporal kinematic variables. The variable with discriminative value of sensitivity
and specificity was swing time, which can be classified as the variable with most predictive potential of PD, and the cut-off point found for this variable was 0.48 seconds. Kinematic gait analysis allows discriminating a group of individuals with PD from a group of healthy individuals, with high sensitivity and specificity, through the swing time, which is lower in the group affected by the disease (cut-off=0.48 seconds)

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References

O’Sullivan SB, Schimitz J. Fisioterapia: avaliação e tratamento. 3a ed. São Paulo: Manole; 1993.

Eygelshoven S, van den Hout A, Tucha L, Fuermaier ABM, Bangma DF, Thome J, et al. Are non-demented patients with Parkinson’s disease able to decide about their own

treatment? Park Relat Disord. 2017;38(1):48-53. doi: 10.1016/j.parkreldis.2017.02.02

Braak H, Del Tredici K, Rüb U, De Vos RAI, Jansen Steur ENH, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003;24(2):197-211.

doi: 10.1016/s0197-4580(02)00065-9

Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci. 2001;2(7):492-501. doi: 10.1038/350815645. Souza CFM, Almeida HCP, Sousa JB, Costa PH, Silveira YSS, Bezerra JCL. A doença de parkinson e o processo de envelhecimento motor: Uma revisão de literatura. Rev Neurocienc. 2011;19(4):718-23. doi: 10.34024/rnc.2011.v19.8330

Adams WR. High-accuracy detection of early Parkinson’s Disease using multiple characteristics of finger movement while typing. PLoS One. 2017;30;12(11):188-226. doi: 10.1371/

journal.pone.0188226

Schreglmann SR, Bhatia KP, Stamelou M. Advances in the Clinical Differential Diagnosis of Parkinson’s Disease. Int Rev Neurobiol. 2017;32:79-127. doi: 10.1016/bs.irn.2017.01.007

Schrag A, Horsfall L, Walters K, Noyce A, Petersen I. Prediagnostic presentations of Parkinson’s disease in primary care: A case-control study. Lancet Neurol. 2015;14(1):57-64. doi: 10.1016/

S1474-4422(14)70287-X

Wert DM, Brach J, Perera S, Van Swearingen JM. Gait Biomechanics, Spatial and Temporal Characteristics, and the Energy Cost of Walking in Older Adults With Impaired Mobility.

Phys Ther. 2010;7(1):977-85. doi: 10.2522/ptj.20090316

Plotnik M, Giladi N, Dagan Y, Hausdorff JM. Postural instability and fall risk in Parkinson’s disease: Impaired dual tasking, pacing, and bilateral coordination of gait during the “oN”

medication state. Exp Brain Res. 2011;210(3):529-38. doi: 10.1007/s00221-011-2551-0

Waters R. Gasto de energia. In: Perry J, editor. Análise da marcha: função normal e patológica. Thorofare: Slack; 2004. p. 443-89.

Fearnley JM, Lees AJ. Ageing and parkinson’s disease: Substantia nigra regional selectivity. Brain. 1991;114(5): 2283-301. doi: 10.1093/brain/114.5.2283

Pagan FL. Improving outcomes through early diagnosis of Parkinson’s disease. Am J Manag Care. 2012; 18(7):176-182.

Wild LB, De Lima DB, Balardin JB, Rizzi L, Giacobbo BL, Oliveira HB, et al. Characterization of cognitive and motor performance during dual-tasking in healthy older adults and patients with Parkinson’s disease. J Neurol. 2013;260(2):580-9. doi: 10.1007/

s00415-012-6683-3

Monteiro EP, Wild LB, Martinez FG, Pagnussat AS, Peyré‐Tartaruga LA. Aspectos biomecânicos da locomoção de pessoas com doença de Parkinson: revisão narrativa. Rev Bras Cienc Esporte. 2017;39(4):450-457. doi: 10.1016/j.rbce.2016.07.003

Hoehn MM, Yahr M. Parkinsonism: onset, progression, and mortality. Neurology. 1967;17(5):427-42. doi: 10.1212/wnl.17.5.427

Hawkes CH, Del Tredici K, Braak H. A timeline for Parkinson’s disease. Park Relat Disord. 2010;16(2):79-84. doi: 10.1016/j.parkreldis.2009.08.007

Pistacchi M, Gioulis M, Sanson F, Giovannini E, Filippi G, Rossetto F, et al. Gait analysis and clinical correlations in early Parkinson’s disease. Funct Neurol. 2017;32(1):28-34.

doi: 10.11138/fneur/2017.32.1.028

Frazzitta G, Balbi P, Maestri R, Bertotti G, Boveri N, Pezzoli G. The beneficial role of intensive exercise on Parkinson disease progression. Am J Phys Med Rehabil. 2013;92(6):523-32.

doi: 10.1097/PHM.0b013e31828cd254

Kleiner A, Galli M, Gaglione M, Hildebrand D, Sale P, Albertini G, et al. The Parkinsonian Gait Spatiotemporal Parameters Quantified by a Single Inertial Sensor before and after

Automated Mechanical Peripheral Stimulation Treatment. Parkinsons Dis. 2015;3(9):5-12. doi: 10.1155/2015/390512

Hollman JH, McDade EM, Petersen RC. Normative spatiotemporal gait parameters inolder adults. Gait and Posture. 2011; 34(1):111-8. doi: 10.1016/j.gaitpost.2011.03.024

Rodriguez KL, Roemmich RT, Cam B, Fregly BJ, Hass CJ. Persons with Parkinson’s disease exhibit decreased neuromuscular complexity during gait. Clin Neurophysiol. 2013;124(7):1390-7. doi: 10.1016/j.clinph.2013.02.006

Warlop T, Detrembleur C, Bollens B, Stoquart G, Crevecoeur F, Jeanjean A, et al. Temporal organization of stride duration variability as a marker of gait instability in Parkinson’s disease. J Rehabil Med. 2016;11;48(10):865-71. doi: 10.2340/16501977-2158

Słomka K, Juras G, Sobota G, Bacik B. The reliability of a rambling-trembling analysis of center of pressure measures. Gait Posture. 2013;37(2):210-3. doi: 10.1016/j.gaitpost.2012.07.005

Kamieniarz A, Michalska J, Brachaman A, Pawłowski M, Słomka KJ, Juras G. A posturographic procedure assessing balance disorders in Parkinson’s disease: a systematic review. Clin

Interv Aging. 2018;12(13):2301-16. doi: 10.2147/CIA.S18089

Published

2023-02-23

Issue

Section

Original Research

How to Cite

Swing time as a predictive variable for Parkinson’s disease. (2023). Fisioterapia E Pesquisa, 28(1), 95-100. https://doi.org/10.1590/1809-2950/20028228012021