Transformação leucêmica do microambiente das células-tronco hematopoiéticas
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i6e-174413Palavras-chave:
Microambiente tumoral, Leucemia, Hematopoese, Células-troncoResumo
O microambiente das células-tronco hematopoiéticas é responsável por coordenar diversos eventos envolvidos na produção de células sanguíneas. Essa renovação hematopoiética só é possível graças às interações e sinalizações bem ordenadas que mantém a harmonia do tecido. Nas leucemias ocorre ruptura nesses mecanismos de controle e ocorre processo de transformação leucêmica do microambiente, de forma a favorecer a manutenção neoplásica do tecido sanguíneo. O objetivo deste estudo foi expor o processo de transformação leucêmica do microambiente, no âmbito das modificações celulares e moleculares sofridas para sustentar o tumor. Trata-se de um artigo de revisão narrativa e as bases de dados Pubmed, Scielo, Cocrahne Library e MedLine foram consultadas em busca de publicações dos últimos anos sobre o tema. Os dados apresentados contribuem para o entendimento holístico acerca das leucemias. A transformação leucêmica, seja por mutações primárias nos componentes do microambiente ou pelo sequestro de suas funções normais pelas células iniciadoras de leucemia, é relevante para que ocorra a instalação, a progressão, a disseminação e a quimiorresistência tumoral. Por meio da atuação de vários componentes este microambiente sustenta as células-tronco leucêmicas e representa caminho promissor para o desenvolvimento de novas terapias antileucêmicas.
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Copyright (c) 2022 Maria Thereza Carvalho Rodriguez Guisande, Lorrany Junia Lopes de Lima, Gabriel Santos Costa, Jarbas Delmoutiez Ramalho Sampaio Filho, Matheus Rodrigues Lopes
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