The effect of Levamisole on the immune of guinea pigs treated with an inactivated foot-and-mouth, disease vaccine (FMDV)

Abstract

The protection titer of an inactivated tricalent “O", “A" and “C” Foot-and-Mouth disease (FMD) vaccine was assayed in two groups of 96 guinea pigs, one of them received levamisole at an animal daily dose of 2,5 mg/kg during the three days starting the day of the FMD vaccination and the other one was used as control. The range of vaccine dilutions was 10^{-0, OOO}, 10^-602, 10^{-1, 204} e 10^-1,806 and animals were challenged at 21 days after vaccination with 158 DG₅₀ of FMD virus type “C” Waldmann. Although no significant difference was detected between the protection vaccine titer of the two groups, a paired analysis of each vaccine dilution result revealed a favorable effect of levamisole when the vaccine was used at a dilution 10^{-1,806 .}