Effectiveness of papain gel in venous ulcer treatment: randomized clinical trial

Authors

  • Ana Luiza Soares Rodrigues Hospital Federal da Lagoa
  • Beatriz Guitton Renaud Baptista de Oliveira Universidade Federal Fluminense; Escola de Enfermagem
  • Débora Omena Futuro Universidade Federal Fluminense; Faculdade de Farmácia
  • Silvia Regina Secoli Universidade de São Paulo; Escola de Enfermagem

DOI:

https://doi.org/10.1590/0104-1169.0381.2576

Abstract

;;OBJECTIVE:;

; to assess the effectiveness of 2% papain gel compared to 2% carboxymethyl cellulose in the treatment of chronic venous ulcer patients.

;;;;METHOD:;

; randomized controlled clinical trial with 12-week follow-up. The sample consisted of 18 volunteers and 28 venous ulcers. In the trial group, 2% papain gel was used and, in the control group, 2% carboxymethyl cellulose gel.

;;;;RESULTS:;

; the trial group showed a significant reduction in the lesion area, especially between the fifth and twelfth week of treatment, with two healed ulcers and a considerable increase in the amount of epithelial tissue in the wound bed.

;;;;CONCLUSION:;

; 2% papain gel demonstrated greater effectiveness in the reduction of the lesion area, but was similar to 2% carboxymethyl cellulose gel regarding the reduction in the amount of exudate and devitalized tissue. Multicenter research is suggested to evidence the effectiveness of 2% papain gel in the healing of venous ulcers. UTN number: U1111-1157-2998

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Published

2015-06-01

Issue

Vol. 23 No. 3 (2015)

Section

Original Articles

License

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Including names of authors whose contribution does not fit into the above criteria cannot be justified. Those names can be included in the Acknowledgements section.
 Authors are fully responsible for the concepts disseminated in their manuscripts, which do not necessarily reflect the editors’ and editorial board’s opinion.

 

How to Cite

Effectiveness of papain gel in venous ulcer treatment: randomized clinical trial. (2015). Revista Latino-Americana De Enfermagem, 23(3), 458-465. https://doi.org/10.1590/0104-1169.0381.2576