Research on Anti-inflammatory Targets and Mechanisms of alkaloids in Picrasma quassioides Benn Through Network Pharmacology
Keywords:
Picrasma quassioides (D.Don) Benn;, Alkaloids;, Inflammation;, Network pharmacology;, Molecular docking.Abstract
This study aimed to investigate the molecular mechanism of Picrasma quassioides Benn against inflammation by means of network pharmacology. The paper will provide a reference for multi-target and multi-channel treatment of inflammation with traditional Chinese medicine. Through screening and analysis, 11 active ingredients and 109 anti-inflammation prediction targets were obtained and constructed a compound-target network. The targets such as VEGFA, TLR4 and STAT3 may play a crucial role. Network enrichment analysis showed that the 109 potential targets constitute a number of pathways or inflammatory reactions closely related to inflammation, including NF-κB signaling pathway and MAPK signaling pathway. The docking results indicated that the binding energy of Picrasidine Y and the inflammatory factors VEGFA is the highest. This study predicted the role of multiple active compounds in the alkaloids of Picrasma in the inflammatory response, and provided a theoretical basis for the anti-inflammatory mechanism of Picrasma.
Downloads
References
Alolga RN, Nuer-Allornuvor GF, Kuugbee ED, Yin X, Ma G. Ginsenoside Rg1 and the control of inflammation implications for the therapy of type 2 diabetes: A review of scientific findings and call for further research. Pharmacol Res. 2020;152:104630.
Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000;25(2):187-191.
Arts RJ, Joosten LA, Dinarello CA, Kullberg BJ, van der Meer JW, Netea MG. TREM-1 interaction with the LPS/ TLR4 receptor complex. Eur Cytokine Netw. 2011;22(1):11-14.
Baldassare JJ, Bi Y, Bellone CJ. The role of p38 mitogen- activated protein kinase in IL-1β transcription. J Immunol. 1999;162(9):5367.
Galdiero MR, Marone G, Mantovani A. Cancer inflammation and cytokines. Cold Spring Harb Perspect Biol. 2018;10(8):a028662.
Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682-690.
Jiao WH, Gao H, Zhao F, Lin HW, Pan YM, Zhou GX, et al. Anti-inflammatory alkaloids from the stems of Picrasma quassioides BENNET. Chem Pharm Bull (Tokyo). 2011;59(3):359-364.
Khan MR, Kihara M, Omoloso AD. Antibacterial activity of Picrasma javanica. Fitoterapia. 2001;72(4):406-408.
Lee J, Gong YX, Jeong H, Seo H, Xie DP, Sun HN, et al. Pharmacological effects of Picrasma quassioides (D. Don) Benn for inflammation, cancer and neuroprotection (Review). Exp Ther Med. 2021;22(6):1357.
Lee JW, Park JW, Shin NR, Park SY, Kwon OK, Park HA, et al. Picrasma quassiodes (D.Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury. Int J Mol Med. 2016;38(3):834-844.
Li D, Ren W, Jiang Z, Zhu L. Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury. Mol Med Rep. 2018;18(5):4399-4409.
Li K, Fan Y, Xu Z, Xu C. Role of AhR and Foxo1 in skin inflammation in burn animal model via MAPK signaling pathway. Cell Mol Biol (Noisy-le-grand). 2020;66(2):53-58.
Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med. 2013;11(2):110-120.
Lu ZB, Ou JY, Cao HH, Liu JS, Yu LZ. Heat-Clearing Chinese medicines in lipopolysaccharide-induced inflammation. Chin J Integr Med. 2020;26(7):552-559.
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 1997;388(6640):394-397.
Murata M. Inflammation and cancer. Environ Health Prev Med. 2018;23(1):50.
Shin NR, Shin IS, Jeon CM, Hong JM, Oh SR, Hahn KW, et al. Inhibitory effects of Picrasma quassioides (D.Don) Benn. on airway inflammation in a murine model of allergic asthma. Mol Med Rep . 2014;10(3):1495-1500.
Shu B, Liu Z, Jia CY. Research progress on the relationship between acute lung injury/acute respiratory distress syndrome and NF-κB signal transduction. Chin J Injury and Repair (Electronic Edition). 2016;11(02):147-150.
Tao PY, Zhang Y. Bolus of six drugs including rehmannia alleviates inflammation and fibrosis of diabetic nephropathy by regulating NF-κB and TGF-β/Smad dual signaling pathway. J Guangzhou Univ Tradit Chin Med. 2019;36(02):245-250.
Tu C, Wan B, Zeng Y. Ginsenoside Rg3 alleviates inflammation in a rat model of myocardial infarction via the SIRT1/NF-κB pathway. Exp Ther Med . 2020;20(6):238.
Wang N, Li ZY, Zheng XL, Li Q, Yang X, Xu H. Quality assessment of picrasma injection, a traditional chinese medicine preparation, using HPLC combined with chemometric methods and qualitative and quantitative analysis of multiple alkaloids by single marker. Molecules. 2018;23(4):856.
Zhang L, Yu M, Deng J, Lv X, Liu J, Xiao Y. Chemokine signaling pathway involved in CCL2 expression in patients with rheumatoid arthritis. Yonsei Med J. 2015;56(4):1134-1142.
Zhang WZ, Li GY, Qi Q. The regulatory effect of Dioscorea Panthaica Prain et Burkill on TLR4/MyD88/NF-κB signaling pathway in atherosclerotic rats. Chin J Tradit Chin Med. 2020;45(3):602-608.
Zhao F, Chen L, Bi C, Zhang M, Jiao W, Yao X. In vitro anti- inflammatory effect of picrasmalignan A by the inhibitionof iNOS and COX-2 expression in LPS-activated macrophage RAW 264.7 cells. Mol Med Rep . 2013;8(5):1575-1579.
Zhao F, Gao Z, Jiao W, Chen L, Chen L, Yao X. In vitro anti- inflammatory effects of beta-carbolinealkaloids, isolated from Picrasma quassioides, through inhibition of the iNOS pathway. Planta Med. 2012;78(18):1906-1911.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.
The on line journal has open and free access.
