Oral complications in hospitalized children during antineoplastic treatment

Authors

  • Ana Paula Welter Faculdade Meridional/IMED, RS, Brazil
  • Graziela Oro Cericato Faculdade Meridional/IMED, RS, Brazil
  • Luiz Renato Paranhos Federal University of Uberlândia, Uberlândia, Brazil
  • Tito Marcel Lima Santos Federal University of Sergipe, Aracaju, SE, Brazil
  • Lilian Rigo Faculdade Meridional/IMED Passo Fundo, RS

DOI:

https://doi.org/10.7322/jhgd.137142

Keywords:

Chemotherapy, Radiotherapy, Oral Health, Mucositis, Xerostomia.

Abstract

Introduction: Normal cells are also affected during antineoplastic treatment, including oral mucosa cells, which potentially causes oral complications.

Objective: This study aimed to assess the prevalence of the main oral complications and the oral hygiene index in children and adolescents aged 5 to 12 years, who received chemotherapy and/or radiotherapy.

Methods: It is an observational prevalence study performed in a hospital in Southern Brazil. Data were collected from 21 hospitalized patients with a self-application questionnaire for the responsible persons of children and with an intraoral clinical examination. The indicators used were DMFT (decayed, missing, and filled teeth) for dental caries, SOHI (simplified oral hygiene index) for oral hygiene, and the presence of mucositis, xerostomia, and candidiasis.

Results: Most of the sample was male (57.1%) with average age of 8 years (sd 2.92), diagnosed with leukemia (47.6%). All patients received chemotherapy as treatment of choice and 38.1% received radiotherapy as part of the treatment. The results showed the presence of 61.9% of mucositis in patients and 28.6% of xerostomia. No patient presented candidiasis during clinical examination. As for dental caries, 66.7% of patients showed a DMFT from 4 to 16, which is considered high, and 38.1% of patients showed the presence of bacterial plaque and dental calculus.

Conclusion: It is concluded that the main oral complications in children during antineoplastic treatment were mucositis and xerostomia. It was observed a high rate of dental caries as a consequence of an inadequated oral hygiene.

Author Biographies

  • Ana Paula Welter, Faculdade Meridional/IMED, RS, Brazil

    Dentistry student, School of Dentistry

  • Graziela Oro Cericato, Faculdade Meridional/IMED, RS, Brazil

    Professor, School of Dentistry

  • Luiz Renato Paranhos, Federal University of Uberlândia, Uberlândia, Brazil

    Professor, Area of Preventive and Community Dentistry, School of Dentistry

  • Tito Marcel Lima Santos, Federal University of Sergipe, Aracaju, SE, Brazil

    MSc student, Postgraduate Program in Dentistry

  • Lilian Rigo, Faculdade Meridional/IMED Passo Fundo, RS

    Professor, School of Dentistry

References

Figueiredo PBA, Nogueira AJS. Prevalence of Neoplasia, Caries and Gingivitis in Pediatric Cancer Patients in the City of Belém, PA, Brazil. Pesq Bras Odontoped Clin Integr. 2013; 1 3 (2):141-6.

National Cancer Institute. NCI. Available from: http://www.inca.gov.br/tumores_infantis/pdf/9_resultados_comentarios_incidencia_por_tipo_de_cancer.pdf. Accessed in 2016 (25 jun).

Goursand D, Borges CM, Alves KM, Nascimento AM, Winter RR, Martins LHPM, Zarzar PMPA, Paiva SM. Sequelas bucais em crianças submetidas a terapia antineoplásica: causas e definição do papel do Cirurgião-dentista. Arquivos em Odontologia. 2006; 42(3): 161-265.

Lopes IA, Nogueira DA, Lopes IA. Oral Manifestations of Chemotherapy in Children from a Cancer Treatment Center. Pesquisa Brasileira em Odontopediatria e Clínica Integrada. 2012; 12 (1):113-19.

Araujo SNM, Luz MHBA, Silva GRF, Andrade EMLR, Nunes LCC, Moura RO. O paciente oncológico com mucosite oral: desafios para o cuidado de enfermagem. Rev Lat Am Enfermagem. 2015; 23(2):267-74.

Grimald N, Sarmento V, Provedel L, Almeida D, Cunha S. Dental care in prevention and treatment of osteoradionecrosis: literature review. Revista Brasileira de Cancerologia. 2005; 51(4): 319-324.

Silva MAGS, Mendonça EF, Rodrigues KFM, Bariani C, Silva GBL. The utilization of the low energy laser and chlorhexidine 0,12% in the management of oral mucositis due to chemotherapy in children with leukemia. Robrac. 2006; 15(6): 24-31.

Kroetz FM, Czlusniak GD. Oral alterations in juvenile patients submitted to radiotherapy and chemotherapy. Publication UEPG Ciências Biológicas e da Saúde. 2003; 9(2): 41-48.

Barbosa AM, Ribeiro DM, Caldo-Teixeira AS. Knowledge and practices of oral health on hospitalized children with cancer. Ciência & Saúde Coletiva. 2010; 15 (1):1113-22.

Morais EF, Lira JA, Macedo RA, Santos KS, Elias CT, Morais ML. Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leukemia. Brazilian journal of otorhinolaryngology. 2014; 80(1): 78-85.

Albuquerque RA, Morais VLL, Sobral APV. Odontologic protocol of attendance the pediatric oncology patients: review of literature. Revista de Odontologia da UNESP. 2007; 36(3):275-280.

Mouchrek Junior, JCEM, Trovão MMA. Mouchrek Junior, JCEM, Trovão MMA. Assessment of the plaque and gingival indices of children with neoplasy submitted to antineoplastic treatment. Revista Brasileira de Odontologia. 2010; 67(1): 101-5.

Zevallos JP, Mallen MJ, Lam CY, Karam-Hage M, Blalock J, Wetter DW, Garden AS, Sturgis EM, Cinciripini PM. Complications of radiotherapy in laryngopharyngeal cancer: effects of a prospective smoking cessation program. 2009; 115 (19): 4636-44.

Grabois MF, Oliveira EXG, Carvalho MS. Access to pediatric cancer care in Brazil: mapping origin-destination flows. Revista de Saúde Pública. 2013;47(2):368-378.

Greene JC, Vermillion JR. The simplified oral hygiene index. The Journal of the American Dental Association. 1964; 68:7-13.

Klein H, Palmer CE. Dental caries in American Indian children. Publ. Hlth Bull. 1937; 239:1-54.

Santos VI, Anbinder AL, Cavalcante ASR. Pediatric patients with leukemia: dental care. Cienc Odontol Bras 2003; 6 (2): 49-57.

Gordón-Núñez MA, Silva Júnior FL, Galvão HC, Souza LB, Pinto LP. Neutropenia and Oral Mucositis: risk factors for Candidiasis in Children with Cancer. Revista Odontológica do Brasil Central. 2010; 18(48): 51-6.

Kung AYH, Zhang S, Zheng LW, Wong GHM, Chu CH. Oral Health Status of Chinese Pediatric and Adolescent Oncology Patients with Chemotherapy in Hong Kong: a Pilot Study. The Open Dentistry Journal. 2015; 9(1): 21-30.

Bueno AC, Magalhaes CS, Moreira AN. Association Between Risk Factors And Oral Complications In Patients With Head And Neck Cancer Treated With Radiotherapy Combined Or Not With Chemotherapy. Pesq Bras Odontoped Clin Integr. 2012; 12(2):187-93.

Kreuger MRO, Savoldi LW, Hoffman S, Diegoli NM. Oral Manifestation in Patients during Chemotherapy treatment at UNACON, Itajaí/SC. Faculdade de Odontologia de Lins/Unimep. 2008; 21(1):39-47.

Sera EAR, Oliveira RV, Mariotto AH, Aquino DR, Scherma AP. Assessment of dental care before and during radiotherapy treatment. Brazilian Society of Periodontology. 2013; 23 (3): 30-8.

Hespanhol LF, Tinoco EMB, Teixeira HGC, Falabella MEV, Assis NMSP. Buccal manifestations in patients submitted to chemotherapy. Ciência & Saúde Coletiva. 2010; 15 (1): 1085-94.

Azher A, Shiggaon N. Oral health status of children with acute lymphoblastic leukemia undergoing chemotherapy. Indian Journal of Dental Research. 2003; 24 (4): 12-5.

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Published

2019-05-06

Issue

Vol. 29 No. 1 (2019)

Section

Artigos Originais

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