Refractory pemphigus foliaceus associated with herpesvirus infection: case report

Autores

  • Nurimar C. Fernandes Universidade Federal do Rio de Janeiro; Hospital Universitário Clementino Fraga Filho
  • Heloisa Rampinelli Universidade Federal do Rio de Janeiro; Hospital Universitário Clementino Fraga Filho
  • Leandro Magalhães de Souza Universidade Federal do Rio de Janeiro; Hospital Universitário Clementino Fraga Filho; Laboratório de Virologia
  • Maria Angélica A. M. Guimarães Universidade Federal do Rio de Janeiro; Hospital Universitário Clementino Fraga Filho; Laboratório de Virologia

Palavras-chave:

Pemphigus, Human Herpesvirus 1, Human Herpesvirus 2, Polymerase chain reaction

Resumo

Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the skin. Infections caused by members of the herpesviridae family have been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not for PF. The present study aimed to investigate the presence of Human herpesvirus (types 1, 2, 3) in corticosteroid refractory skin lesions from a patient with PF, by a Polymerase chain reaction (PCR) assay. The sample collected from cutaneous blisters has tested positive for herpes simplex virus type 1 (HSV1) after sequence analysis of the amplified viral genomic segment. The study concluded that when PF patients present corticosteroid or immunosuppressants refractory lesions, herpetic infection should be considered.

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Publicado

2017-01-01

Edição

v. 59 (2017)

Seção

Relato de Caso

Como Citar

Fernandes, N. C., Rampinelli, H., Souza, L. M. de, & Guimarães, M. A. A. M. (2017). Refractory pemphigus foliaceus associated with herpesvirus infection: case report. Revista Do Instituto De Medicina Tropical De São Paulo, 59, e41. https://www.journals.usp.br/rimtsp/article/view/140689